Fundamental Aspects of Single Molecule and Zeptomole Analysis

Defense Threat Reduction Agency (DTRA) Grant Number: HDTRA1-11-1-0005
Project Title: Fundamental Aspects of Single Molecule and Zeptomole Analysis
Project Number: CBS119923391
PI: Richard M. Crooks, The University of Texas at Austin
Co-PI: Allen J. Bard, The University of Texas at Austin
Co-PI: Keith Stevenson, Skolkovo Institute of Science and Technology
Co-PI: Bo Zhang, University of Washington


For the most recent update, please visit Prof. Crooks's page.

Shown below are all publications from 2010–2016.

1.   Guerrette, J. P.; Oja, S. M.; Zhang, B.“Coupled Electrochemical Reactions at Bipolar Microelectrodes and Nanoelectrodes” Anal. Chem. 201284, 1609–1616 (DOI: 10.1021/ac2028672).
2.   Dumitrescu, I.; Yancey, D. F.; Crooks, R. M. “Dual-Electrode Microfluidic Cell for Characterizing Electrocatalysts” Lab Chip 201212, 986–993 (DOI: 10.1039/C2LC21181E).
3.   Liu, H.; Xiang, Y.; Lu, Y.; Crooks, R. M. “Aptamer-based Origami Paper Analytical Device for Electrochemical Detection of Adenosine” Angew. Chem. Int. Ed. 2012, 51, 28, 6925–6928 (DOI: 10.1002/anie.201202929).
4.   Cox, J. T.; Guerrette, J. P.; Zhang, B.“Steady-State Voltammetry of a Microelectrode in a Closed Bipolar Cell” Anal. Chem. 201284 (20), 8797–8804 (DOI: 10.1021/ac302219p).
5.   Boika, A.; Thorgaard, S. N.; Bard, A. J.“Monitoring the Electrophoretic Migration and Adsorption of Single Insulating Nanoparticles at Ultramicroelectrodes” J. Phys. Chem. B 2013, 117 (16), 4371–4380 (DOI: 10.1021/jp306934g). Note: Invited, special issue.
6.   Oja, S. M.; Wood, M.; Zhang, B. “Nanoscale Electrochemistry” Anal. Chem. 201385 (2)473–486 (DOI: 10.1021/ac3031702).
7.   Alligrant, T. M.; Nettleton, E. G.; Crooks, R. M. “Electrochemical Detection of Individual DNA Hybridization Events” Lab Chip 201313, 349–354 (DOI: 10.1039/c2lc40993c).
8.   Park, J. H.; Zhou, H.; Zhang, B.; Fan, F.-R. F.; Bard, A. J. “Open Circuit (Mixed) Potential Changes Upon Contact Between Different Inert Electrodes Size and Kinetic Effects” Anal. Chem. 201385, 964–970 (DOI: 10.1021/ac3025976).
9.   Guerrette, J. P.; Percival, S. J.; Zhang, B. “Fluorescence Coupling for Direct Imaging of Electrocatalytic Heterogeneity” J. Am. Chem. Soc. 2013135 (2), 855–861 (DOI: 10.1021/ja310401b).
10.   Dasari, R.; Robinson, D. A.; Stevenson, K. J. “Ultrasensitive Electroanalytical Tool for Detecting, Sizing and Evaluating the Catalytic Activity of Platinum Nanoparticles” J. Am. Chem. Soc. 2013, 135 (2), 570–573 (DOI: 10.1021/ja310614x).
11.   Park, J. H.; Boika, A.; Park, H. S.; Lee, H. C.; Bard, A. J. “Single Collision Events of Conductive Nanoparticles Driven by Migration” J. Phys. Chem. C 2013, 117 (13), 6651–6657 (DOI: 10.1021/jp3126494).
12.   Park, J. H.; Thorgaard, S. N.; Zhang, B.; Bard, A. J. “Single Particle Detection by Area Amplification – Single Wall Carbon Nanotube Attachment to a Nanoelectrode” J. Am. Chem. Soc. CommEd2013135 (14), 5258–5261 (DOI: 10.1021/ja4000917).
13.   Fosdick, S. E.; Anderson, M. J.; Nettleton, E. G.; Crooks, R. M. “Correlated Electrochemical and Optical Tracking of Discrete Collision Events” J. Am. Chem. Soc2013135, 5994–5997 (DOI: 10.1021/ja401864k).
14.   Percival, S. J.; Zhang, B. “Electrocatalytic Reduction of Oxygen at Single Platinum Nanowires” J. Phys. Chem. C 2013117 (27), 13928–13935 (DOI: 10.1021/jp400407n).
15.   Robinson, D. A.; Stevenson, K. J. “Uniform Epitaxial Growth of Pt on Fe3O4; Synergistic Enhancement to Pt Activity for the Oxygen Reduction Reaction” J. Mater. Chem. A 20131, 13443–13443 (DOI:10.1039/c3ta12987j). Note: this work is highlighted on the journal's cover page in the November 21, 2013 issue.
16.   Dasari, R.; Walther, B.; Robinson, D. A.; Stevenson, K. J. “Influence of the Redox Indicator Reaction on the Single Nanoparticle Collisions at Mercury and Bismuth Modified Pt Ultramicroelectrodes” Langmuir 201329 (48), 15100–15106 (DOI: 10.1021/la402818g).
17.   Percival, S. J.; Vartanian, N.; Zhang, B. “Laser-pulled Ultralong Platinum and Gold Nanowires” RSC Adv. 20144, 10491–10498 (DOI: 10.1039/c3ra47207h).
18.   Kim, B.-K.; Boika, A.; Kim, J.; Dick, J. E.; Bard, A. J. “Characterizing Emulsions by Observation of Single Droplet Collisions-Attoliter Electrochemical Reactors” J. Am. Chem. Soc. 2014136 (13), 4849–4852 (DOI: 10.1021/ja500713w).
19.   Dasari, R.; Tai, K.; Robinson, D. A.; Stevenson, K. J. “Electrochemical Monitoring of Single Nanoparticle Collisions at Mercury-Modified Platinum Ultramicroelectrodes”ACS Nano 2014(5), 4539–4546 (DOI: 10.1021/nn500045m).
20.   Yoo, J. J.; Anderson, M. J.; Alligrant, T. M.; Crooks, R. M. “Electrochemical Detection of Insulating Beads at Subattomolar Concentration via Magnetic Enrichment in a Microfluidic Device” Anal. Chem. 201486, 4302–4307 (DOI: 10.1021/ac404093c).
21.   Guo, Z.; Percival, S. J.; Zhang, B. “Chemically Resolved Transient Collision Events of Single Electrocatalytic Nanoparticles” J. Am. Chem. Soc. 2014136, 8879–8882 (DOI: 10.1021/ja503656a).
22.   Alligrant, T. M.; Dasari, R.; Anderson, M. J.; Stevenson, K. J.; Crooks, R. M. “Single Nanoparticle Collisions at Microfluidic Microband Electrodes: the Effect of Electrode Material and Mass Transfer” Langmuir 201430, 13462–13469 (DOI: 10.1021/la503628h).
23.   Boika, A.; Bard, A. J. “Electrophoretic Migration and Particle Collisions in Scanning Electrochemical Microscopy” Anal. Chem. 201486, 11666–11672 (DOI: 10.1021/ac502944n).
24.   Castañeda, A. D.; Alligrant, T. M.; Loussaert, J. A.; Crooks, R. M. “Electrocatalytic Amplification of Nanoparticle Collisions at Electrodes Modified with Polyelectrolyte Multilayer Films” Langmuir 201531, 876–885 (DOI: 10.1021/la5043124).
25.   Wood, M.; Zhang, B. “A Bipolar Electrochemical Method for Dynamic in Situ Control of Single Metal Nanowire Growth”ACS Nano 2015, 9, 2454–2464 (DOI: 10.1021/acsnano.5b00139).
26.   Bard, A. J.; Boika, A.; Kwon, S. J.; Park, J. H.; Thorgaard, S. N. Stochastic Events in Nanoelectrochemical Systems. In Nanoelectrochemistry; Mirkin, M. V.; Amemiya, S., Eds.; CRC Press, Boca Raton, FL, 2015; pp 241–292 (DOI: 10.1201/b18066-11).
27.   Boika, A.; Bard, A. J. “Time of First Arrival in Electrochemical Collision Experiments as a Measure of Ultraslow Concentrations of Analytes in Solution” Anal. Chem. 201587 (8), 4341–4346 (DOI: 10.1021/acs.analchem.5b00037).
28.   Dick, J. E.; Hilterbrand, A. T.; Boika, A.; Upton, J. W.; Bard, A. J. “Electrochemical Detection of a Single Cytomegalovirus at an Ultramicroelectrode and its Antibody Anchoring” PNAS 2015112 (17), 5303–5308 (DOI: 10.1073/pnas.1504294112).
29.   Robinson, D. A.; Yoo, J. J.; Castañeda, A. D.; Gu, B.; Dasari, R.; Crooks, R. M.; Stevenson, K. J. “Increasing the Collision Rate of Particle Impact Electroanalysis with Magnetically Guided Pt-decorated Iron Oxide Nanoparticles” ACS Nano 20159, 7583–7595 (DOI: 10.1021/acsnano.5b02892).
30.   Yoo, J. J.; Kim, J.; Crooks, R. M. “Direct Electrochemical Detection of Individual Collisions between Magnetic Microbead/Silver Nanoparticle Conjugates and a Magnetized Ultramicroelectrode” Chem. Sci. 20156, 6665–6671 (DOI: 10.1039/c5sc02259b).
31.   Lebègue, E.; Anderson, C. M.; Dick, J. E.; Webb, L. J.; Bard, A. J. “Electrochemical Detection of Single Phospholipid Vesicle Collisions at a Pt Ultramicroelectrode” Langmuir 201531 (42), 11734−11739 (DOI: 10.1021/acs.langmuir.5b03123).
32.   Alligrant, T. M.; Dasari, R.; Stevenson , K. J.; Crooks, R. M. “Electrocatalytic Amplification of Single Nanoparticle Collisions using DNA-modified Surfaces” Langmuir 201531 (42), 11724–11733 (DOI: 10.1021/acs.langmuir.5b02620).
33.   Oja, S. M.; Fan, Y. S.; Armstrong, C. M.; Defnet, P.; and Zhang, B. “Nanoscale Electrochemistry Revisited” Anal. Chem. 201688, 414–430 (DOI10.1021/acs.analchem.5b04542).
34.   Hao, R.; Fan, Y. S.; and Zhang, B. “Electrocatalytic Reduction of Silver Chloride on Single Metal Nanoparticles” J. Electrochem. Soc. 2016163, H3145–H3151 (DOI: 10.1149/2.0191604jes).
35.   Robinson, D. A; Kondajji, A. M; Castañeda, A. D.; Dasari, R.; Crooks, R. M.; and Stevenson, K. J. “Addressing Colloidal Stability for Unambiguous Electroanalysis of Single Nanoparticle Impacts” J. Phys. Chem. Lett. 20167, 2512–2517 (DOI: 10.1021/acs.jpclett.6b01131).
36.   Castañeda, A. D.; Robinson, D. A.; Stevenson, K. J.; and Crooks, R. M. “Electrocatalytic Amplification of DNA-modified Nanoparticle Collisions via Enzymatic Digestion” Chem. Sci. 2016, Advance Article (DOI: 10.1039/c6sc02165d).
37.   Robinson, D. A.; Duay, J.; Kondajji, A. M.; and Stevenson, K. J. "Mechanistic Aspects of Hydrazine-induced Pt Colloid Instability and Monitoring Aggregation Kinetics with Nanoparticle Impact Electroanalysis" Faraday Discuss., 2016, Advance Article (DOI: 10.1039/c6fd00121a).
38.   Percival, S. J.; and Zhang, B. "Fast-Scan Cyclic Voltammetry Allows Determination of Electron-transfer Kinetic Constants in Single Nanoparticle Collision" J. Phys. Chem. C, 2016, Advance ASAP (DOI: 10.1021/acs.jpcc.5b11330).
39.   Fan, Y.; Han, C.; and Zhang, B. "Recent Advances in the Development and Application of Nanoelectrodes" Analyst, 2016, Advance Article (DOI: 10.1039/c6an01285j).
40.   Dick, J. E.; Lebègue, E.; Strawsine, L. M.; and Bard, A. J. "Millisecond Coulometry via Zeptoliter Droplet Collisions on an Ultramicroelectrode" Electroanalysis, 2016, Advance Article (DOI: 10.1002/elan.201600182).