Cell Membrane Permeability using SECM

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Cell Membrane Permeability using SECM [download] download
Cell Membrane Permeability using SECM
Authors:Dipankar Koley
Maintainer email:dipankarkoley@yahoo.com
Upload by:koley
Platform: COMSOL Multiphysics
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Cell Membrane Permeability using SECM
This is the simulation discussed in Koley D, Bard AJ (2010) Triton X-100 concentration effects on membrane permeability of a single HeLa cell by scanning electrochemical microscopy (SECM). Proceedings of the National Academy of Sciences of the United States of America 107:16783-7 (www.pnas.org/cgi/doi/10.1073/pnas.1011614107). A redox mediator in solution undergoes a simple one-electron transfer. The SECM tip is held at diffusion-controlled potential to avoid any kinetics complications. Fick’s second law of diffusion in cylindrical coordinates with axial symmetry simulates the transport of redox species toward and away from the electrode surface, driven by concentration gradients. The 2-D simulation is solved by the finite element method, where the mesh is increased in exponential grid fashion at the regions where sharp change in the concentration gradients were noticed. The simulation was originally performed with Comsol Multiphysics 3.3 on a 2.8 GHz Intel Pentium IV processor and 2 GB RAM desktop PC.